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本产品仅用于科研，不用于临床

英文名称 Anti-phospho-RGS19（Ser22）
中文名称 磷酸化G蛋白信号转导调节因子19抗体
别 名 RGS19（phospho S22）; RGS19（phospho Ser22）; G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子
蛋白分子量 predicted molecular weight: 25kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human RGS19 around the phosphorylation site of Ser22 [PP（p-S）M]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS （regulators of G protein signaling） family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling.
Function : Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G（i）a3 > G（i）a1 > G（o）a >> G（z）a/G（i）a2. Activity on G（z）-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Subunit : Interacts with GIPC PDZ domain.
Subcellular Location : Membrane; Lipid-anchor.
Tissue Specificity : Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Post-translational modifications : Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
Similarity : Contains 1 RGS domain.
Database links : UniProtKB/Swiss-Prot: P49795.1
宿主：Human、Murine、Rat （Rattus）、Bovine、Dog （Canine）等物种
磷酸化G蛋白信号转导调节因子19抗体 应用范围: WB, ELISA, IP, IHC （p）, IHC （f）, IF
缓冲液：0.01m PBS,pH值7.4和10毫克/毫升BSA
储存液：0.1%（w/v）*                                                         

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