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本产品仅用于科研，不用于临床

英文名称 Anti-EDR1/PHC1
中文名称 早期发育调控蛋白1抗体
别 名 Early development regulatory protein 1; EDR1 PH1; hPH1; mPH1; PH1; Polyhomeotic-like protein 1; Rae28; PHC1_HUMAN.
浓 度 1mg/1ml
说 明 书 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
产品类型 一抗
研究领域 细胞生物 发育生物学 干细胞 转录调节因子 表观遗传学
蛋白分子量 predicted molecular weight: 105kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from Human EDR1/PHC1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM （sterile alpha motif） domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximay 4.5% of the human genome.
Function : PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The Polycomb group （PcG） genes are essential for maintenance of appropriate expression patterns of developmental master regulators, such as Hox genes, and thus are essential for proper development. PHC1 is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. PHC1, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Subcellular Location : Nuclear.
Similarity : Contains 1 FCS-type zinc finger.
Contains 1 SAM （sterile alpha motif） domain.
Database links : UniProtKB/Swiss-Prot: P78364.3

宿主：Human、Murine、Rat （Rattus）、Bovine、Dog （Canine）等物种
早期发育调控蛋白1抗体应用范围: WB, ELISA, IP, IHC （p）, IHC （f）, IF
缓冲液：0.01m PBS,pH值7.4和10毫克/毫升BSA
储存液：0.1%（w/v）

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